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The main defenses against oxidant damage are provided by different enzymatic systems, aided by low molecular weight antioxidant and electron-rich molecules

Yu H, Mistry J, Nicar MJ, Khosravi MJ, Diamandis A, Van Doorn J et al

[12] Aging in both sexes is accompanied by profound decreases in GH output and in plasma IGF-I concentrations

While ROS production is a natural response to environmental changes, prolonged exposure to elevated ROS levels or oxidative stress facilitates the occurrence and exacerbation of skin diseases (37)