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Figure 1 Despite significant challenges in managing neurodegenerative diseases, advances in mechanistic understanding are rapidly emerging

From the perspective of an organic chemist, peptide synthesis requires selective acylation of a free amine

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For instance, we have shown that elderly patients with treated hypertension exhibit increased CuZn-SOD activity and elevated GSH levels (28), which may suggest that lowering blood pressure during antihypertensive treatment is at least in part due to a CuZn-SOD-GSH-dependent mechanism