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Similar to NNMT overexpression, MNA-treated hepatocytes show a dose-dependent increase in glucose production, Sirt1 protein expression, G6pc mRNA expression, and Pck1 mRNA expression compared to controls and these changes caused by MNA treatment can be abolished by Sirt1 knockdown [14]

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more serious and/or complex investigations are handled by the appropriate MCIO

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Whether the delivered amount crosses the threshold for therapeutic effect in any given individual also remains unknown

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