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Thus, by utilising antioxidants that target Klf9, premalignant cancer cells proliferation can be suppressed [43, 44]

Cancer metabolism: A therapeutic perspective

BCAT-like1 may complete this job by working as a new substrate

Consistent with this, we observed that KEAP1NRF2 pathway inhibition curtailed the stemness features of chemoresistant MIBC cells, based on the findings that KEAP1 upregulation or NRF2 blockade significantly reduced tumor sphere formation, clonogenic growth and invasiveness, hallmarks of the stem cell-like, therapy-tolerant state