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the first two belonged to Gram-positive bacteria (MRSA and Streptococcus mutans ), the next two belonged to Gram-negative bacteria ( Enterobacter cloaca and Salmonella typhimurium ), and the last one is Candida lipolytica as a yeast species

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More importantly, in the absence of His, Pro was found to play a very important role in Cu binding and the role of other amino acids (threonine, Gln, glycine, and methionine were negligible in presence of His and Pro (Irtelli et al., 2009)

Implication of the proprotein convertases in iron homeostasis: proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin