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5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule nicotinamide N-methyltransferase (NNMT) inhibitor studied for its effects on NAD+ metabolism, cellular energy regulation, and adipose tissue models in preclinical research

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However, development was discontinued in 2007 after the largest Phase IIb trial failed to demonstrate statistically significant weight loss compared to placebo