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The findings from this trial contrasted with those from another open-label nonplacebo-controlled trial that randomized 32 patients to receive oxaliplatin-based chemotherapy with or without oxcarbazepine.[35] The oxcarbazepine arm experienced a significantly reduced incidence of CIPN (31.2% vs 75%)
Patients were diverse regarding race/ethnicity (36% non-Hispanic White, 36% Hispanic, 27% Black), cirrhosis etiology (50% hepatitis C virus, 25% nonalcoholic steatohepatitis, 20% alcohol), and tumor stage (41% early-stage BCLC stage 0/A and 59% BCLC stage B, with 41% being within Milan Criteria)
*Correspondence: Song Li, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers