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Overall, 198 patients were randomized to SSC, and 197 were included in the primary analysis

It should be noted that there is no statistically significant difference in the serum cotinine level between mice exposed to tobacco smoke for 12 and those for 24 weeks, although the average cotinine concentration for mice with 24 weeks of exposure is higher than those with 12 weeks of exposure

This is also supported by research showing that women who smoke are more likely to conceive a chromosomally unhealthy pregnancy (such as a pregnancy affected by Down syndrome) than non-smoking mothers

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