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Serotonin is synthesized from the amino acid tryptophan in a series of chemical reactions, of which the rate-limiting step is catalyzed by the enzyme tryptophan hydroxylase [178, 179], wherein SAMe functions as a methyl-donating cofactor in the rate-limiting step in these synthetic reactions to increase the levels of this neurotransmitter

A comprehensive description of hypoxia-inducible factor 2 inhibitors as anticancer agents: a mini-review

Oxidative stress occurs when reactive compounds like the superoxide anion, hydroxyl radicals, and hydrogen peroxide are not neutralized by antioxidant enzymes and defense systems