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Biochemistry 62 , 899911 (2023)

GPX4 inhibits ROS production by converting glutathione (GSH) to oxidized glutathione (GSSG) and reducing the cytotoxic lipid peroxide (LOOH) to the corresponding alcohol (LOH) [58]

Confirmed objective response rate was 64%, with 9% of patients achieving complete response

In conditions like postural orthostatic tachycardia syndrome (POTS) and dysautonomia, which frequently co-occur with Long COVID, this vascular distress contributes to symptoms like rapid heartbeat, dizziness, and blood pooling