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Graves orbitopathy (GO) is the most prominent and common extrathyroidal manifestation of GD, characterized by the production and accumulation of glycosaminoglycans (especially hyaluronic acid) in the retrobulbar and periorbital tissues causing protrusion of the eyeball and restriction of ocular muscle movement ( Table 1

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The peptide, humanin, was ultimately traced to a tiny snippet of mitochondrial DNApart of the ninety-eight per cent of the human genome that had long been dismissed as junk DNA. Cohens work helped reveal that, in the three-billion-letter book that is our genome, even obscure one-liners can be an important part of the story