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Description

Nrf2 was found to inhibit the NLRP3 inflammasome assembly by buffering ROS and controlling the expression of thioredoxin, which inhibits a protein necessary for NLRP3 complex stabilization, the thioredoxin-interacting protein (TXNIP) (90) (see 3.6 Thioredoxins and ASK1 for further details)

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