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Microbial signals activate NOX, inducing localized ROS production that influences redox sensor proteins in cells, thus affecting their activity (6, 12, 13)

Ethics declarations Competing interests All authors declared the absence of any financial or personal conflicts pertaining to this work

Besides, the authors suggested that the larger size of the macrocycle (cap group) of 34 and 29 compared to that of 13 could allow more extensive contacts at the rim of the pocket and in the shallow grooves surrounding the pocket entrance

Activation of NRF2 Signaling Pathway Delays the Progression of Hyperuricemic Nephropathy by Reducing Oxidative Stress