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NNMT inhibitor development faces challenges

Abbreviations A: Amyloid beta AD: Alzheimers disease ADDF: Alzheimers Drug Discovery Foundation ADRD: Alzheimers disease and related dementias CDR: Clinical Dementia Rating CNS: Central nervous system CSF: Cerebrospinal fluid COX-2: Cyclooxygenase 2 D: Dasatinib D+Q: Senolytic therapy including the combination of Dasatinib and Quercetin FDA: Food and Drug Administration FOXO4: Forkhead box protein O4 FOXO4-DRI: FOXO4-D-Retro-Inverso PET: Positron emission tomography MAPK: Mitogen-activated protein kinas MDM2: Murine double minute 2 mTOR: Mammalian target of rapamycin MRI: Magnetic resonance imaging NFT: Neurofibrillary tangle OPC: Oligodendrocyte precursor cell PI3Kd: Phosphatidylinositol 3-kinase-delta PL: Piperlongumine Q: Quercetin ROS: Reactive oxygen species SToMP-AD: Senolytic Therapy to Modulate the Progression of Alzheimers Disease, acronym for clinical trial USP7: Ubiquitin-specific peptidase 7 TBI: Traumatic brain injury uPAR: Urokinase-type plasminogen activator receptor WAT: White adipose tissue References Mehegan, L., and Chuck Rainville

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AOD-9604 stimulates fat breakdown (fat decomposition or destruction) and inhibits fat generation (preventing food materials rich in fat from being converted into body fat)