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Immunosuppressive function of TME-driven MDSC The TME serves as a critical component in the activation and immunosuppressive function of MDSCs, and emerging evidence suggests that hypoxic conditions within the tumor, particularly through the HIF-1-associated pathway, play a significant component in this process

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Despite with picomolar-level detection capacity, most of the current nanomaterial-based GSH biosensors (Table 1) present several drawbacks for wider biological applications, such as its potential toxicity and immunogenicity, reproducibility on the synthesis of nanomaterials, etc 70

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