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Activation of NF kappa B by the respiratory burst of macrophages

However, the high chloride content compared to normal blood levels of about 100 milliequivalents per liter can cause metabolic acidosis when large volumes are given

Erythroid Nuclear Factor 2 (Nrf2) Pathway and Induction by Ozone Therapy One of the recent most emphasized actions in the literature on the anti-inflammatory action of ozone is based on its effect on the Erythroid Nuclear Factor 2 (Nrf2), which is a powerful transcription factor located inside each cell of the body. The nuclear factor erythroid 2-related factor 2 (Nrf2) is an emerging regulator of cellular resistance to oxidants

In its active state, it binds and activates its effector proteins such as RAF-Kinases, PI3K and RalGDS and activates several cellular signaling pathways including mitogen-activated protein kinase (MAPK) pathway