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Food and Drug Administration FDA, 2005)

The standard care for tendon, ligament, muscle, and bone injuries remains the foundation, and its a foundation built on decades of solid evidence: Conservative treatment : Rest, physical therapy, progressive loading, anti-inflammatory management, and activity modification remain first-line approaches for most musculoskeletal injuries

Fibroblast activity and an adequate oxygen supply are essential for proper collagen deposition Angiogenesis is necessary to supply oxygen, nutrients, and immune cells to the wound site