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Like T-cells, B-cells can be polarized and make different cytokines, particularly IL-10, that have been implicated in controlling the immune response and are involved in CNS autoimmunity ( in vivo studies in the EAE model ( Despite 90% of the population being positive for EBV, only a very small proportion develop MS, indicating that factors beyond EBV are involved in the disease onset in genetically predisposed individuals