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The most common adverse effects are insomnia, dry mouth, nausea, dizziness and anxiety

doi:10.1016/j.jep.2018.03.001

Long-term nicotine use affects digestive health through multiple mechanisms: Altering gut microbiome composition and diversity Changing blood flow patterns to digestive organs Modifying nervous system signaling pathways Creating dependency for normal bowel function For people with Crohn's disease, continuing nicotine use can be particularly harmful

The news comes at a time when CTP still has to sort through many of the premarket tobacco product applications (PMTAs) from the largest vape manufacturers, and as the office has been under recent fire for poor public health communication about the relative risks of e-cigarettes and safer nicotine alternatives