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However, the limited translation of these extracts into effective response in clinical trials, underlined further elucidation of potential candidates

2 S are strictly concentration-dependent, acting as a double-edged sword: at physiological levels it functions as a beneficial signaling molecule, whereas at high concentrations it becomes strongly cytotoxic by inhibiting cytochrome c oxidase (Complex IV) at the end of the mitochondrial respiratory chain, leading to energy depletion ( 2 S in health and disease extremely complex, requiring the body to maintain H 2 S within a narrow steady-state window via a sophisticated metabolic regulatory system (Yang, 2011