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This effect is thought to be mediated through GLP-1 receptors in the cardiovascular system and is generally not clinically significant, though patients with certain arrhythmias or those sensitive to heart rate changes should be monitored

While - MSH/CART neurons are activated, the NPY/AgRP neurons are blocked by leptin

ABBREVIATIONS CnAMPs Coconut Antimicrobial Peptides PAMPs Pathogen-Associated Molecular Patterns DAMPs Damage-Associated Molecular Patterns TLR Toll-Like Receptor TNF- Tumor Necrosis Factor-alpha IL-1 Interleukin-1 beta IL-6 Interleukin-6 NF-B Nuclear Factor Kappa B MAPK Mitogen-Activated Protein Kinase ROS Reactive Oxygen Species IF- Interferon-gamma COX-2 Cyclooxygenase-2 5-LOX 5-Lipoxygenase MIC Minimum Inhibitory Concentration PI3K Phosphoinositide 3-Kinase IRS-1 Insulin Receptor Substrate-1 GSK-3 Glycogen Synthase Kinase-3 beta AMPK AMP-Activated Protein Kinase PPAR- Peroxisome Proliferator-Activated Receptor-gamma DPP-4 Dipeptidyl Peptidase-4 RBC Red Blood Cell HDL High-Density Lipoprotein SOD Superoxide Dismutase CAT Catalase WBC White Blood Cell LDL Low-Density Lipoprotein VLDL Very Low-Density Lipoprotein TC Total Cholesterol TG Triglycerides DPPH 2,2-Diphenyl-1-Picrylhydrazyl NO Nitric Oxide APOP Apoptosis PP blood sugar Postprandial Blood Sugar SREBP1c Sterol Regulatory Element-Binding Protein-1c DGAT2 Diacylglycerol O-Acyltransferase 2 AST Aspartate Aminotransferase ALT Alanine Aminotransferase TLR4/NF-B Toll-Like Receptor 4/Nuclear Factor Kappa B MCP-1 Monocyte Chemoattractant Protein-1 iNOS Inducible Nitric Oxide Synthase Klf4 Kruppel-Like Factor 4 HbA1C Glycated Hemoglobin (Hemoglobin A1C) ACKNOWLEDGMENT Authors thanks their respective institutions for providing opportunity to conduct the review

Natural flavonoids as potential herbal medication for the treatment of diabetes mellitus and its complications