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The investigators used a low-intensity approach, consisting of a 20-minute lecture about the health effects of all forms of tobacco use, followed by information about and samples of pre-portioned single-dose tobacco packets available throughout the U.S

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A study showed that IQOS use in a nightclub increased the background number and mass concentration of particles that exhibited high volatility but did not significantly affect the concentrations of formaldehyde, acetaldehyde and 3-ethenyl pyridine.81 A study on TSNAs (1-demethyl-1-nitrosonicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)) in indoor air showed that NNN and NNK emissions in IQOS aerosols were 10% and 2% of those from Marlboro Gold.82 A comprehensive analysis of airborne constituents emitted from IQOS quantified 31 constituents and targeted screening of 30 compounds in the gas phase and 36 compounds in the particle phase.83 Data showed that only nicotine, glycerol, menthol and acetaldehyde levels were above background levels