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PD is a neurodegenerative disorder characterized by core motor symptomsincluding resting tremor, dystonia, and gait disturbancesfrequently accompanied by non-motor manifestations such as dementia, sleep disorders, and autonomic dysfunction (Volta et al., 2015)

Instead, we demonstrated that Cth -deficient macrophages exhibited alterations in the proteome, decreased NF-B activation, diminished expression of macrophage activation markers, and impaired oxidative phosphorylation and glycolysis