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Once delivered to the CNS via the pidolate pathway, magnesium performs several critical neurological functions: It modulates NMDA receptor activity blocking overactivation while enabling healthy learning and memory signalling Magnesium (Mg) supports GABA receptor function, which is fundamental to managing anxiety and stress responses It upregulates Brain-Derived Neurotrophic Factor (BDNF), a key protein linked to neuroplasticity and cognitive resilience It reduces neuroinflammation by modulating inflammatory pathways, protecting neurons from oxidative and inflammatory stress A 2022 study using human brain organoids a sophisticated 3D model derived from induced pluripotent stem cells found that magnesium pidolate was more effective than magnesium sulphate in increasing GABA receptor levels and BDNF, while simultaneously decreasing NMDA receptor overactivation

Second, most of the dosing conventions people cite come from animal studies and clinical experience, not from large human trials that nailed down the optimal dose, route, and duration

J Cardiothorac Vasc Anesth 16:431436 Rezzani R, Corsetti G, Rodella L, Angoscini P, Lonati C, Bianchi R (2003) CyclosporineA treatment inhibits the expression of metabotropic glutamate receptors in rat thymus