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This could also contribute to pleiotropic health

Under normoxic conditions, HIF-1 is degraded via the ubiquitination pathway mediated by proteins such as prolyl hydroxylase domain (PHD) enzymes and the von HippelLindau (VHL) tumor suppressor protein

Consequently, ACS1 expression is increased in tissue culture-based in vitro medium designed to mimic the relatively nutrient-poor infection environment 23 , suggesting that the reduced fitness of the acs1 in vivo is due to its increased importance to AcCoA production under those nutrient conditions