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B-12 Injections are administered directly into the muscle, allowing the vitamins to enter the bloodstream rapidly

For example, a study published in the Journal of Alternative and Complementary Medicine found that B12 supplements improved endurance and reduced fatigue in athletes

FDA-approved weight loss medications like semaglutide (Wegovy) and tirzepatide (Zepbound) have undergone large-scale clinical trials demonstrating statistically significant weight loss

Two other surrogate markers of B12 deficiency are elevated homocysteine and MCV, although several other nutrient deficiencies can cause these levels to be elevated, so be sure to work with your provider when interpreting any lab test results