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*Correspondence: Shifan Khanday, [email protected]

Processing of samples and LC-MS detection of metabolites GS-NEM, GSSG Samples were treated to a final concentration of 20 mM N-ethyl maleimide (NEM) to alkylate GSH 54

Small-molecule inhibitors of cGAS enzymatic activity (e.g., RU.521, G140, PF-06928215) or STING signaling (e.g., H-151, C-176) have shown promise in preclinical neuroinflammation and neurodegeneration models by suppressing excessive type I interferon and cytokine production [12, 196]