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Still, this does not preclude extramitochondrial CHAC1 from concurrently influencing ferroptosis, as we show that CHAC1 loss significantly spares cytosolic GSH under cystine starvation, a significant factor in the capacity of cells to mitigate lipid peroxidation 11

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Supporting this, studies indicate that treatment with insulin or insulin-sensitizing drugs effectively reduced tau hyperphosphorylation in neurons [132, 133]