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Studies in the peptide have spurred numerous research hypotheses, which include possible sleep regulation via pineal gland stimulation, releasing more melatonin

Researchers with existing copper metabolism concerns (e.g., Wilsons disease models) should account for this in their experimental design

But it also explains why transition periods can look like worsening

Our experience suggests that problems in the watermaze such as thigmotaxis and passive floating are minimized if mice first get accustomed to being removed from their home cage to solve relatively unthreatening problems, before being placed in a large tank of water with no visible means of escape