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doi: 10.4049/jimmunol.168.2.689 190 FischerTAPalmetshoferAGambaryanSButtEJassoyCWalterUet al

One of the primary mechanisms of cyclosporin-induced hepatotoxicity is the production of oxidative stress

The natural compound aconine (AC) inhibits NF-B signaling (suppressing IB and p65 phosphorylation), upregulates the key ferroptosis inhibitor GPX4, downregulates the pro-ferroptotic factor ACSL4, and significantly suppresses the expression of the core osteoclastogenic transcription factors c-Fos and NFATc1

Accordingly, Simultaneous Dual Emission detection helps increase throughput with dual emission AlphaLISA-AlphaPlex assays