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Hooftman, A

At a median follow-up of 27 months, both PFS (HR: 0.07, 95% CI: 0.030.17) and time until PSA progression (HR: 0.09, 95% CI: 0.040.2) favored the 177 Lu-PSMA-617 arm: While the LUNAR trial suggests that the addition of neoadjuvant 177 Lu-PSMA to SBRT provides a 10-month gain in median PFS and hormone therapy-free survival with limited toxicity, important questions/limitations remain: What is the long-term benefit with regard to hard endpoints, such as OS

Kuruma H, Matsumoto H, Shiota M, Bishop J, Lamoureux F, Thomas C, Briere D, Los G, Gleave M, Fanjul A, Zoubeidi A