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doi: 10.3389/fimmu.2022.934695 77 RothhammerV.MascanfroniI

In addition, other GSH depleting drug such as vitamin K 3 or menadione (MEN) causes inhibition of intestinal Ca 2+ absorption, which is related to OS, as judged by a decrease in GSH content and an increment in the total carbonyl group content

Animal studies assessing exposure to high stress or trauma have also reported astrocyte dysfunction, which can lead to extracellular glutamate levels increasing to toxic amounts (i.e., excitotoxicity) (46)