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In humans, a frameshift variant in ADCY10 , coding for the soluble adenylyl cyclase (sAC) responsible for the activation of the cAMPPKA, was detected in two related patients with asthenozoospermia (Figure 3B)

Beal MF

34 In clinical studies involving both animals and humans, a special preparation of Coleus forskohlii, applied directly to the eye, was shown to reduce IOP by increasing intraocular circulation and decreasing aqueous humor inflow into the posterior cavity