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AppA activity was determined in a similar manner to that of PhoA except that the pH optima of the enzyme and absorbance maxima of the chromogenic product meant that a discontinuous assay had to be performed

There are six main substance groups that cause damage to peripheral sensory and motor neurons, resulting in development of CIPN: the platinum-based antineoplastics (particularly oxaliplatin and cisplatin), the vinca alkaloids (particularly vincristine and vinblastine), the epothilones (ixabepilone), the taxanes (paclitaxel, docetaxel), the proteasome inhibitors (bortezomid) and immunomodulatory drugs (thalidomide)

9 Figure 7 Hypothetical schemes for alcohol-mediated alveolar macrophage dysfunction