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Annu Rev Pathol 5:145171

Sertraline is an incredible gray area because there are some studies where they looked at models of what sertraline versus fluvoxamine do, and even though theyre both powerful regulators of the Sigma-1 receptor, in some endpoints that are thought to be Sigma-1 related, they do opposite things, and that might indicate that sertraline is actually a very powerful inhibitor of it