what antioxidant is a cofactor of glutathione peroxidase Oxidants and Antioxidants Glutathione Participation in the Prevention

Application of this assay to analyze plasma from patients with known oxidative stress (sickle cell disease and sepsis) and from a patient with sickle cell disease treated with the antioxidant N-acetylcysteine suggests that cysteine disulfides, in particular protein-bound cysteine, serve as sensitive plasma biomarkers for the extent of oxidative stress and effectiveness of antioxidant treatment

Romijn JA, Coyle EF, Sidossis LS, Gastaldelli A, Horowitz JF, Endert E, Wolfe RR

W.VatnickI.BellA

Although these mice initially exhibit normal cardiac function, they progressively develop left ventricular dilation, reduced fractional shortening, disorganized sarcomeres, and damaged mitochondria with aging, highlighting the essential role of sustained autophagy in maintaining structural integrity and contractile function over time