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Acknowledgments The authors would like to thank the patients for their participation in this study and permission to publish

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

Moving beyond the traditional fragmented perspectives that have limited our understanding and management of the disease, our analysis of current information on ME/CFS represents a significant paradigm shift by synthesising the diseases multifactorial origins into a cohesive model

While the experimental models employed in PD have shown connections to human health, it remains a daunting task to translate mechanisms of action observed in in vitro and in vivo studies of natural compounds to clinical outcomes in human trials, where it is a critical step in drug development