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These mechanisms include: (1) hyperglycemia induces an imbalance in the redox state of iron ions, promoting free radical generation and accelerating ferroptosis ( 2.2 Impact of iron homeostasis imbalance on ferroptosis in DCM and molecular regulatory mechanisms Iron homeostasis refers is the regulation of iron intake, transport, storage, and excretion, which directly impacts cellular energy metabolism, antioxidant defense, and immune responses ( In DCM, blood glucose dysregulation triggers excessive oxidative stress and chronic inflammation, both of which are major contributors to ferroptosis (59)

it can prime patients for addiction

It may influence the balance between pro and antiinflammatory mediators, leading to reductions in local inflammatory responses in injured tissues

(2023, July 15)