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Tacrolimus was shown to activate the TGF-RI/Smad3 pathway, leading to increased transcription and production of IL-37 within gingival epithelial cells

A phase II, Randomized, Double-Blind, placebo-controlled study of Simtuzumab in Combination with FOLFIRI for the second-line treatment of metastatic KRAS Mutant Colorectal Adenocarcinoma