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The transsulfuration pathway starts with the CBS enzyme, which catalyzes the conversion of homocysteine and serine into cystathionine, using pyridoxal 5-phosphate (PLP), the active form of pyridoxine, as a cofactor

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These findings show that, despite targeting similar receptors, psilocybin and lisuride diverge in their neurobiological pathways and behavioral outcomes, shedding light on the mechanisms distinguishing psychedelics from non-psychedelics