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LL-37 is a broad-spectrum antimicrobial peptide that also reduces inflammation and supports tissue healing, especially in the lungs, skin and GI tract

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Processes under astrocyte control including glutamatergic signaling (Beaul et al., 2009) are regulated through the molecular clock, and in addition, extracellular glutamate displays rhythmicity, peaking during the mid-late day (inactive period) in mice

The peptide's unique molecular mechanisms involving angiogenesis pathway activation, growth hormone receptor upregulation, and anti-inflammatory modulation distinguish it from conventional therapeutic approaches and provide biological rationale for its observed effects in experimental models