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I.CuzicS.BrajsaK.MildnerB.BokulicA.SitumK.et al (2007)

In addition to the VHL-HIF-VEGF/vascular endothelial growth factor receptor (VEGFR) pathway, VHL mutations affect signaling regulation in the mTOR and epidermal growth factor receptor (EGFR) pathways, promoting tumor growth (130)

2.1 Mechanistic evidence of natural compounds Preclinical studies have demonstrated that these natural products modulate multiple AD-related pathways including reducing A burden, inhibiting tau hyperphosphorylation, preserving mitochondrial function, and suppressing pro-inflammatory cytokines (Wang et al., 2022b)