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The area under the curve of GTT or ITT was analyzed by GraphPad Prism

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M3 receptors are primarily responsible for the normal contraction of the urinary bladder, although M2 receptors are also present, and my act to oppose sympathetically mediated smooth muscle relaxation mediated by beta-3 receptors (Andersson & Arner, 2004)

It is also involved in cholesterol levels.[ref] Genetic variants in the methylation pathway, including MTHFR, are strongly linked to high homocysteine levels and heart disease in many studies