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Because it is essentially water without sufficient solute, direct intravenous administration can cause red blood cell lysis (hemolysis) due to its hypotonic nature

Secondly, there is an impaired synthesis of cystathionine from L-serine and homocysteine by cystathionine -synthase, leading to a subsequent reduction in the drainage of homocysteine from the methionine cycle to the transsulfuration pathway

However, cases of brain damage caused by PQ began to be reported (Grant et al., 1980

Effects of new steroidal aromatase inhibitor, TZA-2237 and/or chlormadinone acetate on hormone-induced and spontaneous canine benign prostatic hyperplasia.Eur