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Key points Hypoxia is a common feature of particular microenvironments and at sites of immunity and inflammation, resulting in increased activity of the hypoxia-inducible factor (HIF)

This study showed that increases in plasma non-transferrin-bound iron (NTBI) and Hb resulting from stored-blood transfusions contributed to vascular disease-associated mortality through iron-enhanced Hb oxidation and subsequent tissue injury [21]