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10.1038/s41587-022-01448-2 61 WangL.SiX.ChenS.WangX.YangD.YangH.et al (2021)

In MCAS, mast cellswhich line the blood vessels, nerves, and mucosal tissuesbecome hyper-responsive, inappropriately releasing massive amounts of histamine, cytokines, and other inflammatory mediators in response to minor environmental or internal triggers