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To further dissect upstream regulatory signals, we performed integrative bioinformatics analysis of the GSE28424 dataset and identified LCN2, an iron-chelating oncoprotein implicated in ferroptosis resistance ( 2+ accumulation, ROS normalization, GSH restoration, and SLC7A11/GPX4 protein recovery

doi: 10.3389/fncel.2024.1409717 Received 30 March 2024 Accepted 01 May 2024 Published 22 May 2024 Volume 18 - 2024 Edited by Monokesh K

The gut flora interact with toll-like receptors (TLRs) that are the gatekeepers in helping distinguish which antigens are helpful or harmful[93], and composition of the gut flora directly influences intestinal permeability.[94] There is growing data showing a potential therapeutic benefit of probiotics in the treatment of IBS.[95][96][97][98][99] The most positive single-species studies for IBS have shown the specific strain Bifidobacterium infantis ( B