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Betaine, a naturally occurring derivative of choline, plays an important role in various cellular processes due to its function as a methyl donor in the methionine-homocysteine cycle (20)

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10.1016/j.jacc.2017.09.028 80 LijunY.DandanW.YunfeiZ.HongjieW.DazhongC.LangS

However, ROS levels remain at nonlethal levels in normal cells, thus enabling specific targeting of cancer cells