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Methods: Optum US de-identified Clinformatics Data Mart Database (01 Oct 2015 - 30 Sept 2023) was analysed retrospectively

No dedicated human trial of this exact pairing has been published, so the combination rests on mechanism and on each compounds individual data

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Additionally, its muscle-relaxing effects increase the likelihood of obstructive sleep apnea, leading to irregular breathing, snoring, and further impaired sleep quality (Simou, Britton & Leonardi-Bee, 2018)