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J Pediatr 162 , 10041009 e1001, (2013)

1) Muscle Protein Synthesis and Hypertrophy Support IGF-1 signaling couples training to mTOR activation, increasing muscle protein synthesis ability, an effect consistently reported in human-focused reviews , 1 connecting resistance exercise, nutrient timing, and IGF-1 pathway responsiveness

JAMA / New England Journal of Medicine (2010) 2

In fact, ApEn statistical applications have unmasked consistent and signicantly greater secretory disorderliness with advancing age for the GH axisproviding a direct barometer for the strength of the feedback system 28